abstract：:In this paper, we investigated the activation energies of the aggregation−disaggregation self-oscillation induced by the Belousov-Zhabotinsky (BZ) reaction by utilizing the nonthermoresponsive polymer chain in a wide temperature range. This is because the conventional type self-oscillating polymer chain, with thermore...

journal_title：International journal of molecular sciences

authors： Hara Y,Jahan RA

更新日期：2012-12-03 00:00:00

abstract：:The physic nut shrub, Jatropha curcas (Euphorbiaceae), has been considered as a "miracle tree", particularly as a source of alternate fuel. Various extracts of the plant have been reported to have insecticidal/acaricidal or molluscicidal/anthelminthic activities on vectors of medical or veterinary interest or on agric...

journal_title：International journal of molecular sciences

authors： Ratnadass A,Wink M

更新日期：2012-11-30 00:00:00

abstract：:MicroRNAs are noncoding RNA molecules of 18-25 nucleotides that regulate gene expression at the post-transcriptional levels. Recent data revealed that miR-218 played key roles in tumor metastasis. Here, we described the regulation and function of miR-218 in cervical cancer. Overexpression of miR-218 reduced the prolif...

journal_title：International journal of molecular sciences

authors： Li J,Ping Z,Ning H

更新日期：2012-11-28 00:00:00

abstract：:Modern strategies in adipose tissue engineering (ATE) take advantage of the easy harvest, abundance and differentiation potential towards mesenchymal lineages of hADSCs. The controlled conversion of hADSCs to committed adipogenic precursors and further mature adipocytes formation is important for good long-term result...

journal_title：International journal of molecular sciences

authors： Galateanu B,Dinescu S,Cimpean A,Dinischiotu A,Costache M

更新日期：2012-11-27 00:00:00

abstract：:Currently, there is no three-dimensional structure of D-specific dehalogenase (DehD) in the protein database. We modeled DehD using ab initio technique, performed molecular dynamics (MD) simulation and docking of D-2-chloropropionate (D-2CP), D-2-bromopropionate (D-2BP), monochloroacetate (MCA), monobromoacetate (MBA)...

journal_title：International journal of molecular sciences

authors： Sudi IY,Wong EL,Joyce-Tan KH,Shamsir MS,Jamaluddin H,Huyop F

更新日期：2012-11-26 00:00:00

abstract：:A comprehensive proteome map of T-lymphoblastic leukemia cells and its alterations after daunorubicin, doxorubicin and mitoxantrone treatments was monitored and evaluated either by paired comparison with relevant untreated control and using multivariate classification of treated and untreated samples. With the main fo...

journal_title：International journal of molecular sciences

authors： Tyleckova J,Hrabakova R,Mairychova K,Halada P,Radova L,Dzubak P,Hajduch M,Gadher SJ,Kovarova H

更新日期：2012-11-22 00:00:00

abstract：:The MP2 and DFT/B3LYP methods at 6-311++G(d,p) and aug-cc-pdz basis sets have been used to probe the origin of relative stability preference for eclipsed acetaldehyde over its bisected counterpart. A relative energy stability range of 1.02 to 1.20 kcal/mol, in favor of the eclipsed conformer, was found and discussed. ...

journal_title：International journal of molecular sciences

authors： Osman OI,Alyoubi AO,Elroby SA,Hilal RH,Aziz SG

更新日期：2012-11-20 00:00:00

abstract：:To investigate the potential for the utilization of cotton stalk, ammonia hydrothermal treatment was applied to fractionate the samples into aqueous ammonia-soluble and ammonia-insoluble portions. The ammonia-soluble portion was purified to yield lignin fractions. The lignin fractions obtained were characterized by we...

journal_title：International journal of molecular sciences

authors： Kang S,Xiao L,Meng L,Zhang X,Sun R

更新日期：2012-11-16 00:00:00

abstract：:The presence of lysine (Lys) or arginine (Arg) and tryptophan (Trp) are important for the antimicrobial effects of cationic peptides. Therefore, we designed and synthesized a series of antimicrobial peptides with various numbers of Lys (or Arg) and Trp repeats [(KW and RW)(n)-NH(2), where n equals 2, 3, 4, or 5]. Anti...

journal_title：International journal of molecular sciences

authors： Gopal R,Na H,Seo CH,Park Y

更新日期：2012-11-15 00:00:00

abstract：:Response surface methodology (RSM) was employed to optimize the extracellular lipase production by Burkholderia sp. HL-10. Preliminary tests showed that olive oil, tryptone and Tween-80 exhibited significant effects on the lipase production. The optimum concentrations of these three components were determined using a ...

journal_title：International journal of molecular sciences

authors： Lo CF,Yu CY,Kuan IC,Lee SL

更新日期：2012-11-13 00:00:00

abstract：:The aim of this study was to investigate the chemical composition of acetone extracts of the lichens Toninia candida and Usnea barbata and in vitro antioxidant, antimicrobial, and anticancer activities of these extracts together with some of their major metabolites. The chemical composition of T. candida and U. barbat...

journal_title：International journal of molecular sciences

authors： Ranković B,Kosanić M,Stanojković T,Vasiljević P,Manojlović N

更新日期：2012-11-12 00:00:00

abstract：:Förster resonance energy transfer (FRET) is a powerful tool used for many problems in membrane biophysics, including characterization of the lateral distribution of lipid components and other species of interest. However, quantitative analysis of FRET data with a topological model requires adequate choices for the val...

journal_title：International journal of molecular sciences

authors： Loura LM

更新日期：2012-11-08 00:00:00

abstract：:Live-cell microscopy is now routinely used to monitor the activities of the genetically encoded biosensor proteins that are designed to directly measure specific cell signaling events inside cells, tissues, or organisms. Most fluorescent biosensor proteins rely on Förster resonance energy transfer (FRET) to report con...

journal_title：International journal of molecular sciences

authors： Hum JM,Siegel AP,Pavalko FM,Day RN

更新日期：2012-11-07 00:00:00

abstract：:Enzymes containing flavin cofactors are predominantly involved in redox reactions in numerous cellular processes where the protein environment modulates the chemical reactivity of the flavin to either transfer one or two electrons. Some flavoenzymes catalyze reactions with no net redox change. In these reactions, the ...

journal_title：International journal of molecular sciences

authors： Sobrado P

更新日期：2012-11-05 00:00:00

abstract：:The nuclear retinoic acid receptors (RARs) function as ligand-dependent transcriptional regulators and include three subtypes (RARα, RARβ and RARγ), which control the expression of specific gene subsets subsequent to ligand binding and to strictly controlled phosphorylation processes. Extracellular matrix (ECM) accumu...

journal_title：International journal of molecular sciences

authors： Long YB,Qin YH,Zhou TB,Lei FY

更新日期：2012-10-31 00:00:00

abstract：:Three pools of exhaled breath condensate (EBC) from non-smokers plus healthy smokers (NS + HS, n = 45); chronic obstructive pulmonary disease (COPD) without emphysema (COPD, n = 15) and subjects with pulmonary emphysema associated with α(1)-antitrypsin deficiency (AATD, n = 23) were used for an exploratory proteomic ...

journal_title：International journal of molecular sciences

authors： Fumagalli M,Ferrari F,Luisetti M,Stolk J,Hiemstra PS,Capuano D,Viglio S,Fregonese L,Cerveri I,Corana F,Tinelli C,Iadarola P

更新日期：2012-10-29 00:00:00

abstract：:At present, due to the growing attention focused on the issue of tendon-bone healing, we carried out an animal study of the use of genetic intervention combined with cell transplantation for the promotion of this process. Here, the efficacy of bone marrow stromal cells infected with bone morphogenetic protein-2 (BMP-2...

journal_title：International journal of molecular sciences

authors： Dong Y,Zhang Q,Li Y,Jiang J,Chen S

更新日期：2012-10-22 00:00:00

abstract：:MicroRNAs (miRNAs) are a major class of small, noncoding RNA molecules that regulate gene expression by targeting mRNAs to trigger either translational repression or mRNA degradation. They have recently been more widely investigated due to their potential role as targets for cancer therapy. Many miRNAs have been impli...

journal_title：International journal of molecular sciences

authors： Tang J,Ahmad A,Sarkar FH

更新日期：2012-10-18 00:00:00

abstract：:Matrix metalloproteinases (MMPs) play an important role in the degradation of extracellular matrix components crucial for tumor growth, invasion and metastasis. MMPs are controlled by natural inhibitors called tissue inhibitors of metalloproteinases (TIMPs). We and others have demonstrated that MMPs and TIMPs are espe...

journal_title：International journal of molecular sciences

authors： Herszényi L,Hritz I,Lakatos G,Varga MZ,Tulassay Z

更新日期：2012-10-16 00:00:00

abstract：:When cellular reducing enzymes fail to shield the cell from increased amounts of reactive oxygen species (ROS), oxidative stress arises. The redox state is misbalanced, DNA and proteins are damaged and cellular transcription networks are activated. This condition can lead to the initiation and/or to the progression of...

journal_title：International journal of molecular sciences

authors： Pagel JI,Deindl E

更新日期：2012-10-12 00:00:00

abstract：:The present study investigated the expression and clinical role of hyaluronan synthases (HAS1-3) and hyaluronidases (Hyal1-3) in serous ovarian carcinoma. HAS and HYAL mRNA expression was analyzed in 97 tumors (61 effusions, 27 primary carcinomas, 9 solid metastases) using PCR and further studied for association with ...

journal_title：International journal of molecular sciences

authors： Weiss I,Trope CG,Reich R,Davidson B

更新日期：2012-10-10 00:00:00

abstract：:Multiple sclerosis is a potentially debilitating disease of the central nervous system. A concerted program of research by many centers around the world has consistently demonstrated the importance of the immune system in its pathogenesis. This knowledge has led to the formal testing of a number of therapeutic agents ...

journal_title：International journal of molecular sciences

authors： Buzzard KA,Broadley SA,Butzkueven H

更新日期：2012-10-04 00:00:00

abstract：:The risk of prostate cancer has been increasing in men by degrees. To develop a new prostate cancer therapy, we used a stem cell-derived gene directed prodrug enzyme system using human neural stem cells (hNSCs) that have a tumor-tropic effect. These hNSCs were transduced with the therapeutic genes for bacterial cytosi...

journal_title：International journal of molecular sciences

authors： Yi BR,Hwang KA,Kim YB,Kim SU,Choi KC

更新日期：2012-09-28 00:00:00

abstract：:The last few decades have witnessed an increased life expectancy of patients suffering with systemic rheumatic diseases, mainly due to improved management, advanced therapies and preventative measures. However, autoimmune disorders are associated with significantly enhanced cardiovascular morbidity and mortality not f...

journal_title：International journal of molecular sciences

authors： Dimitroulas T,Sandoo A,Kitas GD

更新日期：2012-09-26 00:00:00

abstract：:Peptide/protein aggregation is implicated in many amyloid diseases. Some amyloidogenic peptides/proteins, such as those implicated in Alzheimer's and Parkinson's diseases, contain multiple amyloidogenic domains connected by "linker" sequences displaying high propensities to form turn structures. Recent studies have de...

journal_title：International journal of molecular sciences

authors： Ko A,Kim JR

更新日期：2012-09-25 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic disabling disease of the central nervous system commonly affecting young adults. Pathologically, there are patches of inflammation (plaques) with demyelination of axons and oligodendrocyte loss. There is a global latitude gradient in MS prevalence, and incidence of MS is increasing...

journal_title：International journal of molecular sciences

authors： O'Gorman C,Lucas R,Taylor B

更新日期：2012-01-01 00:00:00

abstract：:It has been a long-standing question how DNA damage repair proceeds in a nuclear environment where DNA is packaged into chromatin. Several decades of analysis combining in vitro and in vivo studies in various model organisms ranging from yeast to human have markedly increased our understanding of the mechanisms underl...

journal_title：International journal of molecular sciences

authors： Adam S,Polo SE

更新日期：2012-01-01 00:00:00

abstract：:Little is known about the interactions of single nucleotide polymorphisms (SNPs) and overweight/obesity on blood pressure levels. The present study was undertaken to detect 10 lipid-related gene SNPs and their interactions with overweight/obesity on blood pressure levels. Genotyping of ATP-binding cassette transporter...

journal_title：International journal of molecular sciences

authors： Yin RX,Wu DF,Aung LH,Yan TT,Cao XL,Long XJ,Miao L,Liu WY,Zhang L,Li M

更新日期：2012-01-01 00:00:00

abstract：:In order to generate an antibody against a small hapten molecule, the hapten is cross-linked with carrier protein to make it immunogenic. In this study, the hapten (Fumonisin B(1), FB(1)) was coupled to ovalbumin (OVA) and bovine serum albumin (BSA), respectively by a short cross-linker reagent (glutaraldehyde, GA). T...

journal_title：International journal of molecular sciences

authors： Wang Y,He CH,Zheng H,Zhang HB

更新日期：2012-01-01 00:00:00

abstract：:An economical and environmentally friendly whey protein fractionation process was developed using supercritical carbon dioxide (sCO(2)) as an acid to produce enriched fractions of α-lactalbumin (α-LA) and β-lactoglobulin (β-LG) from a commercial whey protein isolate (WPI) containing 20% α-LA and 55% β-LG, through sele...

journal_title：International journal of molecular sciences

authors： Yver AL,Bonnaillie LM,Yee W,McAloon A,Tomasula PM

更新日期：2012-01-01 00:00:00

abstract：:A split plot 3 by 4 experiment was designed to characterize the relationship between production of gluthatione (GSH), oxidized gluthatione (GSSG), total flavonoid, anthocyanin, ascorbic acid and antioxidant activities (FRAP and DPPH) in three varieties of Labisia pumila Blume, namely the varieties alata, pumila and la...

journal_title：International journal of molecular sciences

authors： Ibrahim MH,Jaafar HZ,Rahmat A,Rahman ZA

更新日期：2012-01-01 00:00:00

abstract：:Oxylipins generated by the lipoxygenase (LOX) pathway play an important role in plant defense against biotic and abiotic stress. In chitosan-treated Adelostemma gracillimum seedlings, obvious accumulation of 9-LOX-derived oxylipins, namely 9,10,11-trihydroxy-12-octadecenoic acid, was detected. Using degenerate primers...

journal_title：International journal of molecular sciences

authors： Li J,Zhao PJ,Ma CL,Zeng Y

更新日期：2012-01-01 00:00:00

abstract：:The effects of acidic polysaccharides purified from Gastrodia rhizome on blood pressure and serum lipid levels in spontaneously hypertensive rats (SHR) fed a high-fat diet were investigated. Acidic polysaccharides were purified from crude polysaccharides by DEAE-Sepharose CL-6B. Thirty-six male SHR were randomly divid...

journal_title：International journal of molecular sciences

authors： Lee OH,Kim KI,Han CK,Kim YC,Hong HD

更新日期：2012-01-01 00:00:00

abstract：:Recent advances in the field of RNA research have provided compelling evidence implicating microRNA (miRNA) and long non-coding RNA molecules in many diverse and substantial biological processes, including transcriptional and post-transcriptional regulation of gene expression, genomic imprinting, and modulation of pro...

journal_title：International journal of molecular sciences

authors： Zarate R,Boni V,Bandres E,Garcia-Foncillas J

更新日期：2012-01-01 00:00:00

abstract：:Aqueous solutions of isovaline and its precursor molecule, 5-ethyl-5-methylhydantoin, were irradiated with ultraviolet and γ-ray photons, to evaluate their structural stability against space radiation. The degree of photolysis was measured and irradiation products were identified using chiral, reversed-phase and ion-e...

journal_title：International journal of molecular sciences

authors： Sarker PK,Takahashi J,Kawamoto Y,Obayashi Y,Kaneko T,Kobayashi K

更新日期：2012-01-01 00:00:00

abstract：:To design ARC-111 analogues with improved efficiency, we constructed the QSAR of 22 ARC-111 analogues with RPMI8402 tumor cells. First, the optimized support vector regression (SVR) model based on the literature descriptors and the worst descriptor elimination multi-roundly (WDEM) method had similar generalization as ...

journal_title：International journal of molecular sciences

authors： Zhou W,Dai Z,Chen Y,Wang H,Yuan Z

更新日期：2012-01-01 00:00:00

abstract：:In the last several years, researchers have exhibited an intense interest in the evolutionarily conserved signaling pathways that have crucial roles during embryonic development. Interestingly, the malfunctioning of these signaling pathways leads to several human diseases, including cancer. The chemical and biophysica...

journal_title：International journal of molecular sciences

authors： Villaamil VM,Gallego GA,Cainzos IS,Valladares-Ayerbes M,Antón Aparicio LM

更新日期：2012-01-01 00:00:00

abstract：:This study describes the simple synthesis of new (quinazolin-4-ylamino) methylphosphonates via microwave irradiation. Substituted-2-aminobenzonitrile reacted with 1,1-dimethoxy-N,N-dimethylmethanamine at a reflux condition to obtain N'-(substituted-2-cyanophenyl)-N,N-dimethylformamidine (1). The subsequent reaction of...

journal_title：International journal of molecular sciences

authors： Luo H,Hu D,Wu J,He M,Jin L,Yang S,Song B

更新日期：2012-01-01 00:00:00

abstract：:Cancers can cause some proteins to be aberrantly excreted or released in the urine, which can be used as biomarkers. To screen for potential biomarkers for endometrial cancer (ECa), the urinary proteins from patients who were newly diagnosed with early stage ECa and untreated controls were separated using two-dimensio...

journal_title：International journal of molecular sciences

authors： Mu AK,Lim BK,Hashim OH,Shuib AS

更新日期：2012-01-01 00:00:00

abstract：:When Clostridium tetani was discovered and identified as a Gram-positive anaerobic bacterium of the genus Clostridium, the possibility of turning its toxin into a valuable biological carrier to ameliorate neurodegenerative processes was inconceivable. However, the non-toxic carboxy-terminal fragment of the tetanus tox...

journal_title：International journal of molecular sciences

authors： Calvo AC,Oliván S,Manzano R,Zaragoza P,Aguilera J,Osta R

更新日期：2012-01-01 00:00:00